Amoeboid–mesenchymal transition and the proteolytic control of cancer invasion plasticity

Proceedings of the National Academy of Sciences, Volume 123, Issue 15, April 2026. <br/>SignificanceIn vivo, cancer cells exhibit invasion plasticity as they traverse extracellular matrix (ECM) barriers in collective or single-cell fashion while displaying either mesenchymal or amoeboid phenotypes. Current dogma holds that invasion …