Piezo1 dictates K+ homeostasis through coordinated regulation of the ubiquitin ligase Kelch-like 3 in RBCs and the kidney

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceMaintaining potassium (K+) balance is vital for the body and involves multiple organs. This study shows that the mechanosensitive Ca2+channel Piezo1 controls extracellular K+levels by coordinating with KLHL3, the ubiquitin ligase, in both …