A cascade of structural rearrangements positions peptide release factor 2 for polypeptide hydrolysis on the ribosome

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Proceedings of the National Academy of Sciences, Volume 122, Number 46, November 2025.
SignificancePeptide release factor 2 (RF2) plays a crucial role in the release of nascent polypeptide from the ribosome through multiple pathways, from canonical termination of protein synthesis to rescue of ribosomes stalled on aberrant messenger RNAs. …

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