Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Proceedings of the National Academy of Sciences, Volume 122, Issue 36, September 2025. <br/>SignificanceMycobacterium tuberculosis(M.tb) uses specialized secretion systems to export numerous proteins into host cells. Among these, the five extracellular secretion (ESX) systems are believed to shape host–pathogen interactions. Here, we found that …