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Muricholic acid mediates puberty initiation via the hypothalamic TGR5 signaling pathway

https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c

Proceedings of the National Academy of Sciences, Volume 122, Issue 37, September 2025. <br/>SignificanceThe onset of puberty is increasingly observed at earlier ages in children, especially in girls with obesity, while the molecular basis of this phenomenon remains partially unfolded. Since bile acids (BAs) have emerged as pivotal signaling …

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