Wnt inhibition alleviates resistance to anti-PD1 therapy and improves antitumor immunity in glioblastoma

Proceedings of the National Academy of Sciences, Volume 122, Issue 38, September 2025. <br/>SignificanceGBM patients face extremely limited treatment options and poor responses to current immunotherapies. Our findings reveal that targeting the Wnt7b/β-catenin pathway can sensitize stem-cell rich GBM to immune checkpoint blockade, offering a …