In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation

Proceedings of the National Academy of Sciences, Volume 122, number 39, September 2025.
Significant of the type IV DOT / ICM secretion secretion system to transform effective proteins through the bacterial envelope into host cells, ultimately leading to severe legionnaire disease. Here we determine the quasi-atomic in situ …