Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance

Proceedings of the National Academy of Sciences, Volume 122, Issue 39, September 2025. <br/>SignificanceResistance to bedaquiline, a cornerstone drug for treating multidrug-resistant tuberculosis, is rapidly emerging due to mutations that upregulate expression of the MmpS5L5 efflux pump. Using cryo-EM and structural modeling, we reveal the …