Sp140L functions as a herpesvirus restriction factor suppressing viral transcription and activating interferon-stimulated genes

Proceedings of the National Academy of Sciences, Volume 122, Issue 25, June 2025. <br/>SignificanceHerpesviruses, including the oncogenic Epstein–Barr virus (EBV), are restricted by DNA sensing during initial infection and therefore encode viral proteins to antagonize key restriction factors. We found that the EBV latency protein EBNA-LP …