Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility

Proceedings of the National Academy of Sciences, Volume 122, Issue 40, October 2025. <br/>SignificanceDisordered autoimmunity 1 (DIORA1) has been genetically linked to multiple autoimmune rheumatic diseases, but its cellular function has remained unknown. In this study, we identify DIORA1 as a direct interactor of Myotonic Dystrophy Kinase-…