Biliverdin reductase A is a major determinant of protective NRF2 signaling

Proceedings of the National Academy of Sciences, Volume 122, Issue 40, October 2025. <br/>SignificanceWhile biliverdin reductase A (BVRA) is classically known as the biosynthetic enzyme for the metabolite and antioxidant bilirubin, we report here that it also exerts nonenzymatic antioxidant activity by modulating the activity of the …