NFL DFS picks, lineup advice, daily Fantasy strategy guide for Monday Night Football
The Week 6 NFL schedule concludes with a “Monday Night Football” doubleheader. The Atlanta Falcons host the Buffalo Bills at 7:15 p.m. ET, and the Washington Commanders host the Chicago Bears at 8:15 p.m. ET. Both games have an over/under of 49.5 points, meaning fantasy points are coming in bunches on MNF. The Bills are 3.5-point favorites, while the Commanders are -5.5 in their respective matchups, so those potential game flows could play into NFL DFS strategy. The NFL DFS player pool consists of Josh Allen, James Cook, Bijan Robinson, Jayden Daniels and Caleb Williams. All should be popular NFL DFS picks and centerpieces of NFL DFS lineups. Terry McLaurin (quad) is the most notable player who was ruled out.
What are the best NFL DFS picks for Bills vs. Falcons and Bears vs. Commanders, and which daily Fantasy sleepers should you target to differentiate your NFL DFS lineups and NFL DFS stacks? Before making any NFL DFS picks for Monday Night Football on sites like DraftKings and FanDuel, be sure to check out SportsLine’s daily NFL Fantasy expert Jimmie Kaylor’s NFL DFS lineup tips, strategy and player stacks.
Taylor is a NFL betting and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He topped more than 355,000 other entrants in the contest and also has several five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for nearly a decade as a member of the Pro Football Writers of America, and his experience as a former college and NFL player gives him a unique perspective when it comes to building his fantasy teams and locking in his betting picks.
Now, Kaylor has turned his attention to “Monday Night Football” and just locked in his top daily fantasy football picks. You can only see his Monday Night Football DFS picks and analysis at SportsLine.
New users can get $50 in Pick6 credits at DraftKings when they play $5:
Top NFL DFS Picks, Lineups and Stacks for Monday Night Football
One of Kaylor’s top DFS picks for “Monday Night Football” is Bills quarterback Josh Allen, who has a plus/minus of 232.5 passing yards and 34.5 rushing yards. The former Wyoming star was outstanding in 2024, throwing for 3,731 yards with 28 touchdowns against just six interceptions and adding 12 rushing touchdowns, earning his first NFL MVP award. He guided the Bills to a 13-4 record and a deep playoff run, although they ultimately fell short in the AFC Championship Game.
In 2025, Allen continued his elite form, throwing for 1,217 yards, nine touchdowns and two interceptions in five games. His dual-threat ability remains one of Buffalo’s biggest assets, constantly putting pressure on defenses with his arms and legs, making him an elite fantasy quarterback option. See who else to sign up here.
Part of Kaylor’s optimal NFL DFS strategy also includes aligning Falcons running back Bijan Robinson. The former Texas star had a breakout year in 2024, totaling 1,456 yards on 304 carries (4.8 yards per carry) and scoring 14 rushing touchdowns. He also caught 61 passes for 431 yards and a touchdown, cementing his status as one of the most complete backs in the league.
In 2025, through four games, Robinson has already collected 314 rushing yards on 64 carries (4.9 yards per carry) and added 18 receptions for 270 receiving yards and a touchdown. His dual-threat profile continues to make him a focal point of Atlanta’s game plan, forcing defenses to respect both his running and receiving skills. You can see the rest of Kaylor’s NFL DFS picks here.
New users can see the latest FanDuel promo code has get $300 bonus bets at FanDuel if your $5 bet wins:
How to Create NFL DFS Lineups for Monday Night Football
Kaylor is also targeting another undervalued player who could explode with huge numbers on “Monday Night Football.” This choice could be the difference between winning your tournaments and cash games or going home with nothing. You can just see who it is, and get the rest of Kaylor’s NFL DFS picks, at SportsLine.
So who is Jimmie Kaylor included in his optimal NFL DFS lineups for Monday Night Football’s doubleheader, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see the optimal NFL DFS picks, rankings, tips and stacks, all from SportsLine’s proven DFS expert who won a millionaire-making tournament in one game, and find out.
