An Orc6 tether mediates ORC binding-site switching during replication origin licensing

Proceedings of the National Academy of Sciences, Volume 122, Issue 41, October 2025. <br/>SignificanceBidirectional DNA replication is critical for accurate and complete duplication of the genome. Eukaryotic organisms coordinate this through loading of two oppositely oriented Mcm2-7 replicative helicases at origins of replication. Using single-…