Parkinsonism disrupts the balance between excitatory and inhibitory activity within the primary motor cortex during movement

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Proceedings of the National Academy of Sciences, Volume 122, Number 42, October 2025.
ImportanceThe primary motor cortex (M1) is an essential component for movement generation via corticospinal projections. In this study, we focused on how Parkinsonism alters M1 neuronal spiking activity during a reaching task. We observed a…

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