The insulin-like peptides Dilp2 and Dilp6 exhibit divergent responses to dietary sugar and protein in Drosophila larvae

Proceedings of the National Academy of Sciences, Volume 122, Issue 42, October 2025. <br/>SignificanceTheDrosophila melanogastergenome encodes multiple insulin-like peptides (Dilps) that bind to a single-known insulin receptor to control growth and metabolism. Here, we show that dietary nutrients regulate two of these hormones, Dilp2 and …