Monocyte-derived exosomal periostin driven by histone lactylation contributes to retinal neovascularization

Proceedings of the National Academy of Sciences, Volume 122, Issue 44, November 2025. <br/>SignificanceNeovascularization in retinopathy is a major cause of irreversible vision loss. While local hypoxia and ischemia in the retina are well-established pathogenic factors driving retinal neovascularization (RNV), the contribution of systemic …