Week 11 NFL picks, score predictions, best bets today from self-learning AI


The NFL’s Week 11 schedule features nine divisional matchups. Among the biggest are Sunday, when the Seattle Seahawks and Los Angeles Rams, co-leaders of the AFC West, face off as Sam Darnold looks to guide the Seahawks past Matthew Stafford and the Rams. Another key division matchup features the Kansas City Chiefs taking on the Denver Broncos in a crucial AFC West meeting. The Rams are 3-point favorites, while Kansas City is favored by 3.5 points on the road.
A non-division matchup with heavy implications for the NFC playoff race pits the Detroit Lions against the Philadelphia Eagles (-2.5). Philadelphia has won the last two meetings, the last by 38-35 in 2022. The largest margin of the week is the Patriots (-12.5) on Thursday Night Football against the Jets, while the largest Sunday margin is the Ravens (-7.5) over the Cleveland Browns despite the uncertainty surrounding Lamar Jackson, who missed practice with a knee injury on Wednesday. Other big favorites include the Packers (-7) against the Giants and the Texans (-6.5) against the Titans.
Before making any NFL Week 11 picks or NFL score predictions on these or other games, you need to view the NFL vs. spread, over/under and money line predictions powered by SportsLine’s self-learning AI.
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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI predictions and AI ratings are generated for each game. AI predictions are determined by learning statistically from each team’s historical data and then quantitatively assessing the strength of the opponent’s defense by assigning a numerical value out of 100 called a match score. It continually updates with the most recent data available and can help you spot the biggest gaps in lines. SportsLine’s AI PickBot has reached over 2,000 4.5 and 5 star prop picks since the start of the 2023 season.
For Week 11 NFL betting, the AI PickBot evaluated the NFL odds and provided NFL betting picks for all 15 games. Here you can only see the AI predictions for the NFL Week 11 schedule.
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Top NFL AI Picks from Week 11
After analyzing every game in Week 11, the AI says the Dallas Cowboys (-3.5, 50.5) are comfortably covering the struggling Las Vegas Raiders on “Monday Night Football.” Dak Prescott leads the Dallas offense, completing 69.3 percent of his passes for 2,319 yards and 17 touchdowns with six interceptions. He also rushed 29 times for 121 yards (4.2 average) and a touchdown. He has thrown three or more touchdowns in four of his last six games.
Las Vegas has struggled as of late, losing three straight to fall to 2-7 overall, including a lackluster 10-7 loss to the Denver Broncos on “Thursday Night Football” last week. SportsLine AI rates the Cowboys as an A+ pick on the money line and also predicts a 29-21 win on average. Check out his other Week 11 football predictions and football picks at SportsLine, and bet on the Cowboys here:
How to make Week 11 NFL picks
Additionally, the AI PickBot generated well over 20 highly coveted A+ picks for Week 11. You need to see the AI’s NFL picks before making your own NFL bets for Week 11. You can only see them at SportsLine.
Who is winning and covering every NFL Week 11 game, and which A+ picks should you target now? Visit SportsLine now to see the best NFL picks against the spread, above and on the money line, all sourced from SportsLine’s AI that has managed more than 2,000 highly rated picks since the start of the 2023 season.

