Long-chain unsaturated free fatty acids control gut motility via nitrergic ganglia of the enteric nervous system

Proceedings of the National Academy of Sciences, Volume 122, Issue 45, November 2025. <br/>SignificanceThis study identifies nitrergic enteric neurons as direct chemosensors of luminal long-chain unsaturated free fatty acids (LUFFAs), notably ω-3 fatty acids (EPA/DPA/DHA), that suppress intestinal motility through a noncanonical pathway …