Structural basis for a potent human neutralizing antibody targeting a conserved epitope on the H7 hemagglutinin head

Proceedings of the National Academy of Sciences, Volume 122, Number 45, November 2025.
SignificanceThe high-resolution cryo-EM structure indicates that the human 6Y13 antibody binds strongly to a conserved pan-H7 epitope on the hemagglutinin head, distinct from the receptor binding site and side patch. However, 6Y13 can largely…