‘Monday Night Football’ prediction, odds: 49ers-Panthers picks from expert on 18-4 run

Teams looking to stay in the mix in their respective divisions face off when the Carolina Panthers take on the San Francisco 49ers on “Monday Night Football.” Carolina is coming off a 30-27 overtime victory over the Atlanta Falcons, while San Francisco earned a 41-22 win over the Arizona Cardinals in Week 11. The Panthers (6-5), who are second in the NFC South, are 3-3 on the road this season. The 49ers (7-4), third in the NFC West, are 2-2 on their home field in 2025.

Kickoff from Levi’s Stadium in Santa Clara, California is scheduled for 8:15 p.m. ET. San Francisco is a 7-point favorite in the latest Panthers vs. 49ers odds, while the over/under in total points scored is 49.5. Before you lock in any 49ers vs. Panthers picks, be sure to check out what SportsLine NFL expert Micah Roberts has to say, given his mastery of picks in games involving the 49ers.

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Micah Roberts has worked in the Las Vegas sports betting industry for more than 20 years, including 13 years as book manager of Station Casinos. Armed with an elaborate network of sources, Roberts has unrivaled information across multiple sports. More importantly, Roberts knows the pulse of the 49ers. He is 18-4 (+1360) over his last 22 picks against the spread in games involving San Francisco. Anyone who followed him could be very high.

Now, Roberts turned his attention to the Panthers versus the 49ers. You can head over to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines for Niners vs. Panthers:

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How to make 49ers vs. Panthers picks

For Monday night’s game, Roberts exceeds the total. The Panthers have gone over in six of their last 10 games, while the 49ers have gone 7-2-1 in their last 10 games. Teams have totaled 49 points or more in three of their last four meetings. Bryce Young is coming off a monster performance in the win over Atlanta, throwing for 448 yards and three touchdowns. Brock Purdy threw three touchdown passes in a win over Arizona in his first game since September 28.

Roberts also found a critical X-factor that has him jumping to one side of the gap. You can see what it’s like at SportsLine and get your first month at SportsLine for just $1 when you use promo code CHAMPIONSHIP.

Who covers the Panthers against the 49ers and what critical X-factor do you need to know? Visit SportsLine now to see which side of the 49ers vs. Panthers spread you should jump to, all from the expert who has returned $1,360 to $100 to players over his last 22 picks in San Francisco.and find out.