A chromatin-linked CPL2–PHD2/3 module sustains multiple DNA methylation pathways and Polycomb silencing

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. <br/>SignificanceEpigenetic silencing in plants involves diverse pathways, but how they are integrated into a coherent repression system remains obscure. We reveal the CPL2–PHD2/3 module as a chromatin‐responsive hub that preserves CHH methylation through both …