Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics

Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
ImportanceCreatine kinase (CK) is a key enzyme in brain bioenergetics, whose activity is altered in various neurological disorders. This study introduces a CK imaging (CKI) method to map CK transmission rate constants throughout the brain in vivo. …