Ribonuclease RNase Z is an evolutionarily conserved deAMPylase

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Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
ImportanceSelenoprotein O (SelO) is a conserved AMPylase present in bacteria and humans, highlighting its fundamental role in cellular regulation. While AMPylases act as writer enzymes by attaching AMP to proteins, the identity of the corresponding gum…

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