Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair
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Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
ImportanceDNA polymerase theta (Pol θ) initiates the repair of double-strand breaks using microhomologies (MH). This process, known as theta (Pol θ)-mediated end joining (TMEJ), is particularly important in homolog-defective cancer cells…
