Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

Proceedings of the National Academy of Sciences, Volume 122, Number 47, November 2025.
ImportanceMitochondrial DNA (mtDNA) plays a crucial role in energy metabolism, cell signaling and the development of human diseases. Although it is known that mtDNA is susceptible to damage, the biological consequences of this damage remain partially…