Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior

Proceedings of the National Academy of Sciences, Volume 122, Number 48, December 2025.
SignificanceGiant Ankyrin-G (gAnkG) is the major organizing protein of the axon initial segment (AIS), a specialized subcellular domain essential for the initiation of action potentials. Here, we demonstrate that a mutation in gAnkG alters…