NFL picks for Week 15, score predictions, best bets today from self-learning AI


The Week 15 NFL schedule includes 16 additional games, including several with potential playoff ramifications. One of those games is an AFC East battle between the Buffalo Bills (9-4) and the New England Patriots (11-2). Buffalo is favored by 1.5 points as Josh Allen and the Bills take on Drake Maye and the Patriots. Buffalo is on a two-game winning streak, while New England has won 10 in a row. Another key matchup will pit two NFC contenders as the Detroit Lions (8-5) take on the Los Angeles Rams (10-3). The Lions are fighting for a playoff spot, while the Rams look to maintain the conference’s No. 1 seed.
The Rams enter as 5.5-point home favorites. Sunday’s biggest spreads include Raiders vs. Eagles (-11), Titans vs. 49ers (-12.5) and Jets vs. Jaguars (-12.5). Before making any NFL picks for Week 15 or NFL score predictions on these or other games, you need to view the NFL vs. spread, over/under and money line predictions powered by SportsLine’s self-learning AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI predictions and AI ratings are generated for each game. AI predictions are determined by learning statistically from each team’s historical data and then quantitatively assessing the strength of the opponent’s defense by assigning a numerical value out of 100 called a match score. It continually updates with the most recent data available and can help you spot the biggest gaps in lines. SportsLine’s AI PickBot has reached over 2,000 4.5 and 5 star prop picks since the start of the 2023 season.
For Week 15 NFL betting, SportsLine AI evaluated NFL odds and provided NFL betting picks for all 15 games. Here you can only see the AI predictions for the NFL Week 15 schedule.
Top NFL AI Picks of Week 15
After analyzing every game in Week 15, the AI says the Cowboys (-5.5), who have won three of their last four games, cover comfortably against the Vikings.
Quarterback Dak Prescott is on a roll. In 13 games, he completed 69% of his passes for 3,637 yards and 26 touchdowns with 10 interceptions for a rating of 100.2. Bet Prescott will go over 37.5 yards for the longest completion using the last DraftKings promo codewhich offers $200 bonus bets if your first bet wins:
Powering the Dallas rushing attack is fifth-year veteran running back Javonte Williams. In 13 games, he has carried 215 times for 1,022 yards (4.8 average) and nine touchdowns. He has five explosive plays of 20 yards or more, including a long of 66 yards. SportsLine AI rates the Cowboys as an A+ spread pick and also predicts a 30-20 win on average. See its other Week 15 football predictions and football picks at SportsLine, and bet the Cowboys at DraftKings here:
How to make Week 15 NFL picks
In addition, the AI PickBot has generated more than two dozen highly-coveted A picks for Week 15. You need to see the AI’s NFL picks before making any Week 15 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 15 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.




