Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition | Science
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
The CRL4CRBN E3 Ubiquitin Ligase is the target of the compounds of degrading of molecular glue which reprogramly the specificity of the ligase to induce the degradation of clinically relevant neosubstate proteins. The known cereblon (CRBN) neosubstates share a generalizable β -..
