A ferritin-like diiron oxygenase BioE initiates bacterial biotin synthesis, a promising antivirulence target

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificanceBiotin is an essential enzyme cofactor, and inhibitors of its biosynthesis could provide alternative antibiotics. We show that bacteria from the Weeksellaceae family access the universal biotin precursor, pimelic acid, by a distinct pathway …