Structural insights into the role of eIF3 in translation mediated by the HCV IRES

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. <br/>SignificanceVarious RNA viruses utilize RNA elements called internal ribosomal entry sites (IRESs) to hijack host ribosomes. The Hepatitis C virus (HCV) IRES binds to eukaryotic initiation factor 3 (eIF3), the multisubunit complex that acts as a versatile …