A metabolic cell death program downstream of SARM1 couples NAD+ depletion to BAX activation and APAF1 degradation

Proceedings of the National Academy of Sciences, Volume 122, Number 50, December 2025.
ImportanceThe loss of the essential metabolic cofactor Nicotinamide adenine dinucleotide (NAD+) following neuronal activation of the NADase SARM1 is a potent trigger of axonal degeneration and neuronal death, but how this signal executes the cell death program…