Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. <br/>SignificanceThe ability to distinguish self from nonself is an essential part of innate immunity and multicellularity. In the amoebaDictyostelium discoideum,cells form transient multicellular structures via aggregation. In the process, they exclude …