Study uncovers how calcium controls insulin quality in the endoplasmic reticulum

Calcium (Ca2+) drives many cellular functions, although how it controls protein quality in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, has not been elucidated. This protein quality control system, known as proteostasis, was put under the microscope by researchers to better understand the process, potentially revealing clues about how to prevent type 2 diabetes, Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).