Lipid-packing defects are sufficient to modulate membrane insertion and the bound state of α-synuclein

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificanceWe show through tryptophan fluorescence that lipid-packing defects (low lipid-packing density) are required for α-synuclein–membrane insertion, while net negative charge is not. We additionally find that on lower defect membranes, the bound …