Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A

Proceedings of the National Academy of Sciences, Volume 122, Issue 52, December 2025. <br/>SignificancePruritus (itch), a phenomenon associated with various inflammatory skin diseases including psoriasis and atopic dermatitis, remains a major unmet clinical need with few effective treatments. While sensory hyperinnervation is a hallmark of …