Origin of class B J-domain proteins involved in amyloid transactions

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. <br/>SignificanceAcross prokaryotes and eukaryotes, J-domain proteins (JDPs) are key players in Hsp70 chaperone systems that maintain cellular protein homeostasis. The abundant class A and B JDPs have structural similarities, yet their origin has remained …