SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting

Proceedings of the National Academy of Sciences, Volume 123, Number 2, January 2026.
SignificancePrevious work has demonstrated that the SARS-CoV-2 proteome can potentially be a rich source of AMP-like viral fragments, examples of which are associated with severe COVID-like inflammation in vitro and in vivo. Here we demonstrate that…