Molecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceWhile smoking can accelerate aging through epigenetic alterations, it’s pathobiologic impact is unclear. Using single nuclear ATAC sequencing (snATAC-seq)/snRNA-seq, we report that acute smoke stress induced degenerative heterogeneity from …