Chemical tuning reveals a cation–π gating bridge between the voltage-sensor and pore domains in the Kv7.1 potassium channel

Proceedings of the National Academy of Sciences, Volume 123, Issue 3, January 2026. <br/>SignificanceThis study provides functional evidence of a cation–π interaction within a eukaryotic protein. These interactions have long been proposed to be central to protein function but have eluded characterization due, in part, to limitations in …