TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway

Proceedings of the National Academy of Sciences, Volume 122, number 27, July 2025.
Significant proteins are the transcriptional effectors of the Hippo track and are a promising target for cancer treatment, with several Tead inhibitors that are progressing in the clinic. Medication type Tead inhibitors are developed in order to disturb Tead …