Functionally heterogeneous intratumoral CD4+CD8+ double-positive T cells can give rise to single-positive T cells

Proceedings of the National Academy of Sciences, Volume 123, Number 4, January 2026.
ImportanceCD4+CD8+double-positive T cells, which are classically thymic T precursors, have been described in tumors of cancer patients, but their role in this context is not fully understood. Using single-cell analyses, we show that intratumoral DP…