Conformationally gated multisite proton-coupled electron transfer in the ribonucleotide reductase β subunit

Proceedings of the National Academy of Sciences, Volume 123, Number 5, February 2026.
ImportanceThe efficient and regulated movement of protons and electrons underlies many enzymatic processes essential for sustaining life. The ribonucleotide reductase enzyme, essential for DNA synthesis and repair, relies on a precisely tuned network of redox actives…