In situ NMR and integrative proteomics reveal the interaction signature of serum α-synuclein

Proceedings of the National Academy of Sciences, Volume 123, Issue 5, February 2026. <br/>SignificanceAlpha-synuclein (αS) is a central protein in Parkinson’s disease (PD) and related synucleinopathies, yet its behavior outside neurons remains poorly understood. This study reveals that αS engages in distinct, region-specific interactions in …