Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer

Proceedings of the National Academy of Sciences, Volume 123, Issue 5, February 2026. <br/>SignificanceIslet amyloid polypeptide (IAPP) oligomers are toxic intermediates in the protein aggregation pathway that are associated with the development of type 2 diabetes. Mammals besides humans also have IAPP variants that can aggregate, with most …