RPA-independent activation of the ATR/CHK1 pathway
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 123, Number 6, February 2026.
SignificanceThe ATR/CHK1 signaling pathway is a central gatekeeper of genome integrity, canonically considered to be dependent on RPA-coated single-stranded DNA for its activation. Using an acute RPA2-degron system, we discovered an unexpected RPA-independent pathway to…
