Dual inhibition of mTOR and calcineurin pathways mitigates missing self–induced NK cell–mediated microvascular rejection

Proceedings of the National Academy of Sciences, Volume 123, Number 7, February 2026.
SignificanceOur translational study focused on a mechanism of microvascular rejection driven by natural killer (NK) cells activated by recognition of “missing self”, independent of traditional donor-specific antibody-mediated pathways. Our study…