Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels
https://www.profitableratecpm.com/f4ffsdxe?key=39b1ebce72f3758345b2155c98e6709c
Proceedings of the National Academy of Sciences, Volume 123, Number 7, February 2026.
SignificanceTMEM16A is a Ca2+-activated chloride channel expressed in various tissues, where it regulates electrical excitability, cell volume, ionic homeostasis, and solute transport. TMEM16A dysfunction is linked to conditions such as hypertension,…
