Nonoxidative pentose phosphate pathway regulates CD8+ T cell immunity by maintaining NADPH homeostasis

Proceedings of the National Academy of Sciences, Volume 123, Number 8, February 2026.
ImportanceThe non-oxidative pentose phosphate (non-oxPPP) pathway, mediated by transketolase (TKT) and transaldolase (TALDO1), is essential for maintaining reduced nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis to drive CD8+T cells…