Plastid 2-oxoglutarate-dependent dioxygenases mediate stereoselective C14β-hydroxylation in cardenolide biosynthesis

Proceedings of the National Academy of Sciences, Volume 123, Issue 8, February 2026. <br/>SignificanceStereo-specific C14β-hydroxylation represents a major bottleneck in the chemical synthesis of cardenolides—compounds that are both structurally and pharmacologically significant in plant defense and medicine. Although multiple plant families …