Capturing ribosomal structures in cellular extracts with cryoPRISM: A purification-free cryoEM approach reveals novel structural states

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Proceedings of the National Academy of Sciences, Volume 123, Number 9, March 2026.
ImportanceThe ribosome plays a central role in cellular physiology, with most resources allocated to translation during proliferation, and ribosomal silencing preserving resources during stress. A structural understanding of how ribosomes assemble,…

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